About FISH Probe
What is a fish probe?
What is a FISH Probe?
These are fluorescently labeled molecular chains that bind to specific DNA or RNA sequences, and are gene detection reagents used in FISH (Fluorescence in Situ Hybridization). They are used to detect and visualize chromosomal abnormalities and specific gene regions, and are an essential tool for analyzing chromosomal translocations, deletions, and amplifications.
How to use a fish probe?
What can be checked with FISH Probe
FISH Probes primarily use illumination to visualize specific genes or chromosome locations, allowing us to check whether their number has increased, whether they have been deleted, or whether they are located in the correct position.
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( 01 )
Gene amplification and deletion
This allows you to check whether a specific gene has been amplified or deleted (missing).
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( 02 )
Gene cutting and isolation
This allows you to check if a specific gene has been cut midway and is not split into an abnormal state.
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( 03 )
Gene translocation and fusion
This allows us to check whether different chromosomes have been swapped (translocation) and whether abnormal fusion genes (such as those that cause cancer or leukemia) have been formed.
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( 04 )
Chromosome excess or deficiency
By fluorescently labeling the central part (centromere) of a chromosome, it is possible to determine how many copies of a particular chromosome there are (whether there is an excess or deficiency in the number).
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( 05 )
Microstructure at the ends of chromosomes
This test can detect changes that are easily overlooked in general tests, such as minute deletions or duplications at the ends of chromosomes (subtelomeres).
Our Products
FISH Probe provided by GSP LAB
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Gene FISH Probe
Products for detecting abnormalities in specific genes
This product is used to identify how target genes are altered within cells, such as through amplification or deletion of specific genes, or through chromosomal aneuploidy.
The following products offer more accurate genetic abnormality detection:
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Split Fish Probe
Gene cutting, isolation, and detection products
This product is used to detect whether a specific gene has been cut (rearranged) midway through its path. The regions flanked by the target gene (the 5′ and 3′ sides of the breakpoint) are fluorescently labeled with different colors.
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Translocation FISH Probe
Chromosomal translocation and fusion gene detection products
This product can pinpoint and detect specific "fusion genes" resulting from chromosomal translocations. It can accurately identify translocations and gene fusions where the genes being combined are known in advance.
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Custom-Designed Fish Probe
Custom FISH Probe Development
We manufacture custom probes tailored to the specific needs of each researcher, addressing any desired genetic abnormality. From customizing existing products to creating entirely original probes, we accommodate a wide range of specifications to suit research objectives, including changes to fluorescence color and brightness, and detection of specific genes and chromosomes.
AP Uniqueness
Possession of a proprietary BAC clone library
We possess approximately 180,000 to 200,000 BAC clones in our proprietary library, which are essential for the development and manufacture of FISH probes. This massive resource, equivalent to about seven times the approximately 30,000 clones needed to cover the entire human genome, allows us to rapidly produce FISH probes targeting any desired chromosomal region.
Our team consists of experts with extensive experience and knowledge.
GSP LAB employs researchers with many years of research experience. Leveraging the scientific knowledge and expertise cultivated through their research, we approach various challenges from a specialized perspective and propose appropriate products and services. We are happy to answer not only specialized research-related consultations but also any questions you may have, so please feel free to contact us.
