製品を使用した論文

（１７６）
Loss of viral genome with altered immune microenvironment during tumour progression of Epstein-Barr virus-associated gastric carcinoma
Pathology, Volume 260, Issue 2, June 2023 : 124-136

（１７５）
SRF split FISH Probe(SP109)/ NOTCH2 ES Translocation FISH Probe(TR047)
PDGFRB and NOTCH3 Mutations are Detectable in a Wider Range of Pericytic Tumors, Including Myopericytomas, Angioleiomyomas, Glomus Tumors, and Their
Modern Pathology, Volume 36, Issue 3, March 2023, 100070

（１７４）
Histological and immunohistochemical prognostic factors of primary angiosarcoma
Virchows Archiv , Published: 01 June 2023

（１７３）
TFE3 split FISH Probe( SP004)
TFE3-immunopositive papillary renal cell carcinoma: A clinicopathological, immunohistochemical, and genetic study
Pathology - Research and Practice, Volume 242, February 2023, 154313

（１７２）
TFEB split FISH Probe(SP078), MALAT1 / TFEB Translocation FISH Probe(TR046)
TFEB-translocated and -amplified renal cell carcinoma with VEGFA co-amplification: A case of long-term control by multimodal therapy A case of long-term control by multimodal therapy including a vascular endothelial growth factor-receptor inhibitor
IJU Case Reports (2023) 6, 161—164

（１７１）
PRDM10 split FISH Probe(SP100)
Usefulness of SynCAM3 and cyclin D1 immunohistochemistry in distinguishing superficial CD34‐positive fibroblastic tumor from its histological mimics
Medical Molecular Morphology , 08 November 2022

（１７０）
ACTN4 / CEN19p FISH Probe, FFPE FISH Kit
Alpha‐actinin‐4 (ACTN4) gene amplification is a predictive biomarker for adjuvant chemotherapy with tegafur/uracil in stage I lung adenocarcinomas
Cancer Sci. 2022 Mar; 113(3): 1002–1009.

（１６９）
CENYq FISH Probe
Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
Cell Reports : Volume 39, Issue 2, 12 April 2022

（１６８）
ROS1 split FISH Probe
Safety and Efficacy of Crizotinib in Combination with Temozolomide and Radiotherapy in Patients with Newly Diagnosed Glioblastoma: Phase Ib GEINO 1402 Trial
Cancers 2022, 14(10), 2393

（１６７）
YWHAE split FISH Probe(SP021)
High-grade Endometrial Stromal Sarcoma: Morphologic and Clinical Features, the Role of Immunohistochemistry and Fluorescence in Situ Hybridization in Diagnosis
SAGE journal

（１６６）
NTRK1 Split FISH Probe, NTRK2 Split FISH Probe, and NTRK3 split FISH Probe
Tropomyosin-Related Kinase Fusions in Gastrointestinal Stromal Tumors
Cancers 2022, 14(11), 2659

（１６５）
MDM2(GC020), PDGFRA (GC091)
Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases
Virchows Archiv 480, 919-925 (2022)

（１６４）
Histological background of dedifferentiated solitary fibrous tumour
JCP : Volume75-6, June 2022

（１６３）
TFEB split FISH Probe(SP078), TFEB-MALAT1 Translocation FISH Probe(TR046)
t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization
IJU Case Reports (2021) 4, 375—378

（１６２）
Neuroectodermal Rosettes in Immature Teratomas Are Not the Counterpart of Embryonal Tumours With Multilayered Rosettes
Anticancer Research September 2022, 42 (9) 4337-4344

（１６１）
TERT / CEN5q FISH Probe(GC124)
Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi
Cell Reports : Volume36, Issue 5, August 2021

（１６０）
SRF Split FISH Probe (SP109), MIR143 / NOTCH2, ES Translocation FISH Probe(TR047)
PDGFRB and NOTCH3 mutations are detectable in a wider range of pericytic tumors, including myopericytomas, angioleiomyomas, glomus tumors, and their combined tumors

（１５９）
SMARCB1 / CEN22q FISH Probe(GC181)
Myxoepithelioid tumour with chordoid features: a clinicopathological, immunohistochemical and genetic study of 14 cases of SMARCB1/INI1-deficient soft-tissue neoplasm
Histopathology : Volume 79, Issue 4, November 2021

（１５８）
FOSB split FISH Probe(SP095), FOS split FISH Probe(SP088)
Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions
JCP, Voiume 49, Issue 9, Sep 2022

（１５７）
EWSR1 split FISH Probe(SP003), CREM split FISH Probe(SP084)
Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion : A Clinicopathologic Study of 8 Cases
The American Journal of Surgical Pathology, Volume 46, Number 1, 4 January 2022, pp. 134-146(13)

（１５６）
1p31/1q25.2 FISH Probe(GC183), 19q13.12/19p13.2 FISH Probe(GC195)
Droplet digital PCR assay for detecting TERT promoter mutations in patients with glioma
Brain Tumor Pathology 2021 : 14 June 2021

（１５５）
FOS Split FISH Probe (SP088), VIM Split FISH Probe (SP105), FOSB Split FISH Probe (SP095)
Recurrent FOS rearrangement in proliferative fasciitis/proliferative myositis
MODERN PATHOLOGY : 14 December 2020

（１５４）
NF2/CEN22q FISH Probe(GC003) and MTAP/CEN9q FISH Probe (GC206)
Reactive mesothelial hyperplasia mimicking mesothelioma in an African green monkey (Chlorocebus aethiops)
Primate Biol., 7, 5–12, 2020

（１５３）
RET split Dual Color FISH Probe (SP018)
Prognostic significance of cribriform adenocarcinoma of the lung: validation analysis of 1,057 Japanese patients with resected lung adenocarcinoma and a review of the literature
Transl Lung Cancer Res. 2021 Jan; 10(1): 117–127.

（１５２）
c-met/CEN7q Dual Color FISH Probe (GC004)
Histological characteristics of lung adenocarcinoma with uncommon actionable alterations: special emphasis on METexon 14 skipping alterations
Histopathology : 9 November 2020 (First published)

（１５１）
PDGFRA/CEN4p Dual Color FISH Probe (GC091)
Platelet‐derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients
GLIA : Volume68, Issue5, May 2020, Pages 979-988

（１５０）
NF2/CEN22q Dual Color FISH Probe (GC003) and MTAP/CEN9q Dual Color FISH Probe (GC206)
Reactive mesothelial hyperplasia mimicking mesothelioma in an African green monkey (Chlorocebus aethiops)
Primate Biol., 7, 5–12, 2020

（１４９）
c-met/CEN7q Dual Color FISH Probe (GC004)
Mechanisms of Acquired Resistance to Savolitinib, a Selective MET Inhibitor in MET-Amplified Gastric Cancer
JCO Precision Oncology., Published online: March 24, 2020

（１４８）
RREB1 /MRTFB (=MKL2) transcription, SY Dual Color FISH Probe (TR043)
Mesenchymal tumours with RREB1–MRTFB fusion involving the mediastinum: extra‐glossal ectomesenchymal chondromyxoid tumours?
Histopathology : 28 January 2020 (First published)

（１４７）
CREM Split Dual Color FISH Probe(SP084)
EWSR1-CREM fusion in pulmonary mesenchymal neoplasm showing distinctive clear cell morphology
Pathol Int . 2020 Oct 1. doi: 10.1111/pin.13030. Online ahead of print.

（１４６）RET Split Split Dual Color FISH Probe(SP018)
Discohesive growth pattern (Disco-p) as an unfavorable prognostic factor in lung adenocarcinoma: an analysis of 1062 Japanese patients with resected lung adenocarcinoma
Mod Pathol . 2020 Sep;33(9):1722-1731. doi: 10.1038/s41379-020-0537-9. Epub 2020 Apr 20.

（１４５）BCOR Split Dual Color FISH Probe(SP063)
A Case Series of BCOR Sarcomas With a New Splice Variant of BCOR/CCNB3 Fusion Gene
In Vivo . Sep-Oct 2020;34(5):2947-2954. doi: 10.21873/invivo.12125.

（１４４）WT1/CEN11p Dual Color FISH Probe(GC143)
A sporadic case of congenital aniridia caused by pericentric inversion inv(11)(p13q14) associated with a 977 kb deletion in the 11p13 region
BMC Med Genomics . 2020 Sep 18;13(Suppl 8):130. doi: 10.1186/s12920-020-00790-1.

（１４３）TFE3 Split Dual Color FISH Probe(SP003)
Primary alveolar soft part sarcoma of the rectum resected by endoscopic submucosal dissection: A case report
Pathol Int . 2020 Aug;70(8):581-586. doi: 10.1111/pin.12955. Epub 2020 Jun 8.

（１４２）IGH/FOXP1, DY Translocation Dual Color FISH Probe(TR017)
t(3;14)(p14.1;q32)/FOXP1-IGH translocation in thyroid extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
Leuk Res . 2020 Aug;95:106399. doi: 10.1016/j.leukres.2020.106399. Epub 2020 Jun 2.

（１４１）MEAF6 Split Dual Color FISH Probe(SP103)
Detection of MEAF6-PHF1 translocation in an endometrial stromal nodule
Genes Chromosomes Cancer . 2020 Aug 20. doi: 10.1002/gcc.22892. Online ahead of print.

（１４０）PDGFB Split Dual Color FISH Probe(SP009)
Establishment and characterization of NCC-DFSP3-C1: a novel patient-derived dermatofibrosarcoma protuberans cell line
Hum Cell . 2020 Jul;33(3):894-903. doi: 10.1007/s13577-020-00365-3. Epub 2020 Apr 30.

（１３９）MTAP/CEN9q Dual Color FISH Probe(GC206),
NF2/CEN22q Dual Color FISH Probe(GC003)
Reactive mesothelial hyperplasia mimicking mesothelioma in an African green monkey ( Chlorocebus aethiops)
Primate Biol . 2020 Jun 15;7(1):5-12. doi: 10.5194/pb-7-5-2020. eCollection 2020.

（１３８）RET Split Dual Color FISH Probe(SP022)
Large nest micropapillary pattern of lung adenocarcinoma has poorer prognosis than typical floret pattern: analysis of 1,062 resected tumors
Transl Lung Cancer Res . 2020 Jun;9(3):587-602. doi: 10.21037/tlcr-19-731.

（１３７）PTEN/CEN10p Dual Color FISH Probe(GC019)　
Deficiency of PTEN and CDKN2A Tumor-Suppressor Genes in Conventional and Chondroid Chordomas: Molecular Characteristics and Clinical Relevance
Onco Targets Ther . 2020 May 25;13:4649-4663. doi: 10.2147/OTT.S252990. eCollection 2020.

（１３６）NF2/CEN22q Dual Color FISH Probe(GC003)
Hemizygous loss of NF2 detected by fluorescence in situ hybridization is useful for the diagnosis of malignant pleural mesothelioma
Mod Pathol . 2020 Feb;33(2):235-244. doi: 10.1038/s41379-019-0309-6. Epub 2019 Jun 23.

（１３５）BAP1/CEN3q Dual Color FISH Probe(GC097)
NF2/CEN22q Dual Color FISH Probe(GC003),
Fluorescence in situ hybridization (FISH) provides estimates of minute and interstitial BAP1, CDKN2A, and NF2 gene deletions in peritoneal mesothelioma
Mod Pathol . 2020 Feb;33(2):217-227. doi: 10.1038/s41379-019-0371-0. Epub 2019 Sep 30.

（１３４）CCND2 Split Dual Color FISH Probe(SP033)
Identification of CD5/Cyclin D1 Double-negative Pleomorphic Mantle Cell Lymphoma: A Clinicopathologic, Genetic, and Gene Expression Study
Am J Surg Pathol . 2020 Feb;44(2):232-240. doi: 10.1097/PAS.0000000000001390.

（１３３）ATF1 Split Dual Color FISH Probe(SP047)
Expanding the phenotypic spectrum of mesenchymal tumors harboring the EWSR1-CREM fusion
Am J Surg Pathol. 2019 Dec;43(12):1622-1630. doi: 10.1097/PAS.0000000000001331.

（１３２）H3F3A/CEN1q Dual Color FISH Probe(GC219)
Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone
Mod Pathol . 2019 Dec;32(12):1751-1761. doi: 10.1038/s41379-019-0318-5. Epub 2019 Jul 8.

（１３１）CSF1 Split Dual Color FISH Probe(SP071)
Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations
Int J Cancer . 2019 Dec 15;145(12):3276-3284. doi: 10.1002/ijc.32421. Epub 2019 May 31.

（１３０）ATF1 Split Dual Color FISH Probe(SP047)
EWSR1 translocation in primary hyalinising clear cell carcinoma of the thymus
Histopathology . 2019 Sep;75(3):431-436. doi: 10.1111/his.13890. Epub 2019 Jul 19.

（１２９）CDK4/CEN12q Dual Color FISH Probe(GC232)
Genetic Aberrations in the CDK4 Pathway Are Associated with Innate Resistance to PD-1 Blockade in Chinese Patients with Non-Cutaneous Melanoma
Clin Cancer Res . 2019 Nov 1;25(21):6511-6523. doi: 10.1158/1078-0432.CCR-19-0475. Epub 2019 Aug 2

（１２８）TFE3 Split Dual Color FISH Probe(SP003)
RBM10-TFE3 renal cell carcinoma characterised by paracentric inversion with consistent closely split signals in break-apart fluorescence in-situ hybridisation: study of 10 cases and a literature review
Histopathology . 2019 Aug;75(2):254-265. doi: 10.1111/his.13866. Epub 2019 Jun 25.

（１２７）TRIM11 Split Dual Color FISH Probe(SP077)
A case report of cutaneous melanocytoma with CRTC1-TRIM11 fusion: Is CMCT distinct from clear cell sarcoma of soft tissue?
Pathol Int . 2019 Aug;69(8):496-501. doi: 10.1111/pin.12826. Epub 2019 Jul 5.

（１２６）BRAF1/CEN7q Dual Color FISH Probe(GC115)
Detection of the KIAA1549-BRAF fusion gene in cells forming microvascular proliferations in pilocytic astrocytoma
PLoS One . 2019 Jul 22;14(7):e0220146. doi: 10.1371/journal.pone.0220146. eCollection 2019.

（１２５）MET/CEN7q Dual Color FISH Probe(GC004)
Liquid biopsy-based comprehensive gene mutation profiling for gynecological cancer using CAncer Personalized Profiling by deep Sequencing
Sci Rep . 2019 Jul 18;9(1):10426. doi: 10.1038/s41598-019-47030-w.

（１２４）MDM2/CEN12p Dual Color FISH Probe(GC020)
Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall
Pathol Int . 2019 Jun;69(6):366-371. doi: 10.1111/pin.12796. Epub 2019 Jun 18.

（１２３）RET Split Dual Color FISH Probe(SP022)
ROS1 Split Dual Color FISH Probe(SP015)
Performance of Oncomine Fusion Transcript kit for formalin‐fixed, paraffin‐embedded lung cancer specimens
Cancer Sci. 2019 Jun; 110(6): 2044–2049.

（１２２）MET/CEN7q Dual Color FISH Probe(GC004)
Combination of Docetaxel Plus Savolitinib in Refractory Cancer Patients: A Report on Phase I Trial
Transl Oncol . 2019 Apr;12(4):597-601. doi: 10.1016/j.tranon.2018.12.009. Epub 2019 Jan 26.

(１２１)NR4A3 Split Dual Color FISH Probe(SP023), EWSR1 split Dual Color FISH Probe (SP003)
Myoepithelioma-like tumor of the vulvar region showing infiltrative growth and harboring only a few estrogen receptor-positive cells: A case report
Pathol Int . 2019 Mar;69(3):172-176. doi: 10.1111/pin.12765. Epub 2019 Feb 9.

(１２０)CEN17q FISH Probe
Viral loads correlate with upregulation of PD-L1 and worse patient prognosis in Epstein–Barr Virus-associated gastric carcinoma
PLoS One. 2019 Jan 29;14(1):e0211358. doi: 10.1371/journal.pone.0211358.
eCollection 2019.

(１１９) TFE3 Split Dual Color FISH Probe(SP004), EWSR1 split Dual Color FISH Probe (SP003)
A novel partner of TFE3 in the Xp11 translocation renal cell carcinoma:
clinicopathological analyses and detection of EWSR1-TFE3 fusion.
Virchows Arch. 2019; 474(3): 389-393

（１１８）FGFR2/CEN10p Dual Color FISH Probe(GC018)
Establishment of a New Scirrhous Gastric Cancer Cell Line with FGFR2 Overexpression, OCUM-14
Annals of Surgical Oncology : April 2019, Volume 26, Issue 4, pp 1093–1102

（１１７）NTRK3 split Dual Color FISH Probe (SP039)
Novel NTRK3 Fusions in Fibrosarcomas of Adults
The American Journal of Surgical Pathology, Volume 43, Number 4, April 2019, pp. 523-530(8)

（１１６）EWSR1 split Dual Color FISH Probe (SP003), NR4A3 Dual Color FISH Probe (SP023)
Myoepithelioma‐like tumor of the vulvar region showing infiltrative growth and harboring only
a few estrogen receptor‐positive cells: A case report
Pathology International : Volume69, Issue3, March 2019, Pages 172-176

（１１５）TFE3 Split Dual Color FISH Probe(SP004)
RBM10‐TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely
Split Signals in Break‐apart Fluorescence in situ Hybridization: Study of Ten Cases and a Literature Review.
Histopathology. 2019 Mar 25. doi:10.1111/his.13866. [Epub ahead of print]

（１１４）MYB split Dual Color FISH Probe(SP016)
Nuclear immunoreactivity of BLM-s, a proapoptotic BCL-2 family member, is specifically detected i
n salivary adenoid cystic carcinoma
Human Pathology : Volume 84, February 2019, Pages 81-91

（１１３）ECT2/CEN3q Dual Color FISH Probe (GC096)
Cytoplasmic expression of epithelial cell transforming sequence 2 in lung adenocarcinoma
and its implications for malignant progression
Laboratory Investigationvolume 99, pages551–567 (2019)

（１１２）EGFR/MET　Dual Color FISH Probe, HRE2/CEN17q Dual Color FISH Probe(GC006),
EGFR/CEN7q Dual Color FISH Probe (GC005), MET/CEN7q Dual Color FISH Probe (GC004)
Changes in HER2 Expression and Amplification Status Following Preoperative Chemotherapy f
or Gastric Cancer in vivo
November-December 2018 : vol.32, No.6, p1491-1498

（１１１）c-met/CEN7q Dual Color FISH Probe (GC004)
Re-evaluation of HER2 status in patients with HER2-positive advanced or recurrent gastric cancer
refractory to trastuzumab (KSCC1604)
European Journal of Cancer : Volume 105, December 2018, Pages 41-49

（１１０）NF2 / CEN22q Dual Color FISH Probe(GC003)
Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary
meningothelial-like nodule and meningioma of the central nervous system
Oncotarget. 2018 Nov 13; 9(89): 36012–36016.

（１０９）FGFR1 split Dual Color FISH Probe (SP026)
Histopathological and genetic review of phosphaturic mesenchymal tumours, mixed connective tissue variant
Histopathology : Volume 72, Issue 3, February 2018, Pages: 460-471

（１０８）KIAA1549/BRAF1,DY Dual Color FISH Probe(TR015)
Comprehensive genetic characterization of rosette‐forming glioneuronal tumors: independent component
analysis by tissue microdissection
BRAIN PATHOLOGY : Volume 28, Issue 1, January 2018, p 87-93

（１０７）CCND1/CEN11p Dual Color FISH Probe (GC010)
Detection of CCND1 Locus Amplification by Fluorescence In Situ Hybridization.
Methods Mol Biol. 2018;1726:85-100. doi: 10.1007/978-1-4939-7565-5_9.

（１０６）MDM2/CEN12p FISH Probe (GC059)、CDK4/CEN12q FISH Probe (GC038)
Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity.
Histopathology. 2018 Jul;73(1):147-156. doi: 10.1111/his.13506. Epub 2018 Apr 19.

（１０５）NTRK1 Split Dual Color FISH Probe (SP025)
Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer.
Transl Oncol. 2018 Jun;11(3):764-770. doi: 10.1016/j.tranon.2018.03.011. Epub 2018 Apr 22.

（１０４）BRAF1/LMO7, DY Translocation　Dual Color FISH Probe (TR028)
Identification of a Recurrent LMO7-BRAF Fusion in Papillary Thyroid Carcinoma.
Thyroid. 2018 Jun;28(6):748-754. doi: 10.1089/thy.2017.0258. Epub 2018 May 16.

（１０３）BAP1/CEN3q FISH Probe (GC097)、NF2/CEN22q FISH Probe (GC003)
Malignant mesothelioma in situ.
Histopathology. 2018 May;72(6):1033-1038. doi: 10.1111/his.13468. Epub 2018 Feb 26.

（１０２）TERT/CEN5q Dual Color FISH Probe (GC124)
Telomerase reverse transcriptase mutations are independent predictor of disease-free survival in Middle Eastern papillary thyroid cancer.
Int J Cancer. 2018 May 15;142(10):2028-2039. doi: 10.1002/ijc.31225. Epub 2017 Dec 29.

（１０１）NF2/CEN22q Dual Color FISH Probe (GC003)
A prolonged response to platinum-based therapy in a patient with metastatic urothelial carcinoma harboring a single rearranged and truncated NF2 gene.
Genes Chromosomes Cancer. 2018 Mar 13. doi: 10.1002/gcc.22537. [Epub ahead of print]

（１００）MDM2/CEN12p Dual Color FISH Probe (GC059)
Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status.
Am J Surg Pathol. 2018 May;42(5):656-664. doi: 10.1097/PAS.0000000000001014.

（９９）LAPTM4B/CEN8q Dual Color FISH Probe (GC117)
LAPTM4B gene copy number gain is associated with inferior response to anthracycline-based chemotherapy in hormone receptor negative breast carcinomas.
Cancer Chemother Pharmacol. 2018 May 16. doi: 10.1007/s00280-018-3602-z. [Epub ahead of print]

（９８）MYB Split Dual Color FISH Probe (SP016)、MYBL1 Split　Dual Color FISH Probe (SP067)
Wnt/β-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland.
Pathol Res Pract. 2018 Apr;214(4):586-592. doi: 10.1016/j.prp.2017.12.016. Epub 2018 Jan 3.

（９７）KIF5B/RET, SY Translocation Dual Color FISH Probe (TR009)
Detection of RET (rearranged during transfection) variants and their downstream signal molecules in RET rearranged lung adenocarcinoma patients.
Surg Oncol. 2018 Mar;27(1):106-113. doi: 10.1016/j.suronc.2018.01.006. Epub 2018 Feb 8.

（９６）HEY1/NCOA2, DY Translocation Dual Color FISH Probe (TR008)
Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion.
Hum Pathol. 2018 Mar 26. pii: S0046-8177(18)30091-1. doi: 10.1016/j.humpath.2018.03.014. [Epub ahead of print]

（９５）MDM2/CEN12p Dual Color FISH Probe (GC059)
Osteosarcoma arising in fibrous dysplasia, confirmed by mutational analysis of GNAS gene.
Pathol Res Pract. 2018 Feb;214(2):318-324. doi: 10.1016/j.prp.2017.10.018. Epub 2017 Nov 12.

（９４）JAK2/CEN9q Dual Color FISH Probe (GC158)
The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling.
Oncotarget. 2017 Oct 23;8(63):106753-106763. doi: 10.18632/oncotarget.22053. eCollection 2017 Dec 5.

（９３）c-met/CEN7q Dual Color FISH Probe (GC004)
Correlation among genetic variations of c-MET in Chinese patients with non-small cell lung cancer.
Oncotarget. 2017 Dec 20;9(2):2660-2667. doi: 10.18632/oncotarget.23474. eCollection 2018 Jan 5.

（９２）CIC Split Dual Color FISH Probe (SP035)
CIC break-apart fluorescence in-situ hybridization misses a subset of CIC-DUX4 sarcomas: a clinicopathological and molecular study.
Histopathology. 2017 Sep;71(3):461-469. doi: 10.1111/his.13252. Epub 2017 Jul 5.

（９１）CD274/CEN9q Dual Color FISH Probe (GC141)
Sensitive detection of PD-L1 expression on circulating epithelial tumor cells (CETCs) could be a potential biomarker to select patients for treatment with PD-1/PD-L1 inhibitors in early and metastatic solid tumors.
Oncotarget. 2017 Aug 18;8(42):72755-72772. doi: 10.18632/oncotarget.20346. eCollection 2017 Sep 22.

（９０）CIC Split (SP035)、EWSR1 Split (SP003)、SYT Split (SP002)
NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma.
Hum Pathol. 2017 Jul;65:225-230. doi: 10.1016/j.humpath.2017.01.012. Epub 2017 Feb8.

（８９）KRAS/CEN12q Dual Color FISH Probe (GC017)
KIF13B-NRG1 Gene Fusion and KRAS Amplification in a Case of Natural Progression of Lung Cancer.
Int J Surg Pathol. 2017 May;25(3):238-240. doi: 10.1177/1066896917693092.

（８８）MDM2/CEN12p Dual Color FISH Probe (GC059)
Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification.
Histopathology. 2018 Apr;72(5):729-738. doi: 10.1111/his.13421. Epub 2017 Dec 22.

（８７）CCNE1/CEN19p Dual Color FISH Probe (GC013)
CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis.
Mod Pathol. 2017 Feb;30(2):297-303. doi: 10.1038/modpathol.2016.160. Epub 2016 Oct 21.

（８６）NTRK1 Split　Dual Color FISH Probe（SP025）
Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient
Oncotarget : 2017 Aug 15; 8(33): 55353–55360.

（８５）CCND2　Split Dual Color FISH Probe（SP033）
Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall
Histopathology. 2017 May;70(6):986-999. doi: 10.1111/his.13161. Epub 2017 Mar 10.

（８４）MDM2/CEN12p Dual Color FISH Probe（GC020）
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma
Pathology - Research and Practice : Volume 213, Issue 6, June 2017, Pages 634-638 (jp)

（８３）MYB Split Dual Color FISH Probe（SP016）
Human papillomavirus-related carcinoma with adenoid cystic-like features: a series of five cases expanding the pathological spectrum
Histopathology. 2017 Jun 30. doi: 10.1111/his.13301. [Epub ahead of print]

（８２）FGF19/CEN11p Dual Color FISH Probe（GC104）
FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas
Thorac Cancer. 2017 Sep 14. doi: 10.1111/1759-7714.12504. [Epub ahead of print]

（８１）BRCA1/CEN17q Dual Color FISH Probe（GC073）
Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers
Cancer Letters : Volume 397, 1 July 2017, Pages 127-132

（８０）ACTN4/CEN19p Dual Color FISH Probe（GC022）
Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer
International Journal of Oral and Maxillofacial Surgery : Volume 46, Issue 8, August 2017, Pages 968-976 (jp)

（７９）FGFR1/CEN8q Dual Color FISH Probe（GC055）
An mRNA Gene Expression–Based Signature to Identify FGFR1-Amplified Estrogen Receptor–Positive Breast Tumors
The Journal of Molecular Diagnostics : Volume 19, Issue 1, January 2017, Pages 147-161

（７８）PIK3CA/CEN3q Dual Color FISH Probe（GC077）
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer
Sci Rep. 2017; 7: 10240.

（７７）VHL/CEN3q Dual Color FISH Probe（GC032）
Sarcomatoid renal cell carcinoma has a distinct molecular pathogenesis, driver mutation profile and transcriptional landscape
Clinical Cancer Research : Published OnlineFirst July 14, 2017

（７６）c-met/CEN7q(GC004), SMO/CEN7q(GC134) Dual color FISH Probe
Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR
Oncotarget. 2017 Apr 4; 8(14): 23020–23032.

（７５）MDM2/CEN12p Dual Color FISH Probe（GC020）
Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status
Human Pathology : Volume 63, May 2017, Pages 63-69 (jp)

（７４）KIAA1549/BRAF1, DY　Dual Color FISH Probe（TR015）
Comprehensive genetic characterization of rosette-forming glioneuronal tumors: independent component analysis by tissue microdissection
Brain Pathol. 2016 Nov 28. doi: 10.1111/bpa.12468. [Epub ahead of print]

（７３）DDR2/CEN1p（GC176）, NTRK1/CEN1p(GC175) Dual Color FISH Probe
Frequent amplification of receptor tyrosine kinase genes in well-differentiated/ dedifferentiated liposarcoma
Oncotarget. 2017 Feb 21; 8(8): 12941–12952. (jp)

（７２）FGF9/CEN13q Dual Color FISH Probe（GC147）
Significance of FGF9 gene in resistance to anti-EGFR therapies targeting colorectal cancer: A subset of colorectal cancer patients with FGF9 upregulation may be resistant to anti-EGFR therapies
Mol Carcinog. 2017 Jan;56(1):106-117. doi: 10.1002/mc.22476. Epub 2016 Feb 24.

（７１）CIC Split Dual Color FISH Probe（SP０３５）
Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes
Virchows Arch. 2017 Apr;470(4):373-380. doi: 10.1007/s00428-017-2072-8. Epub 2017 Feb 14.

（７０）FGFR1 Split Dual Color FISH Probe（SP026）
Histopathological and Genetic Review of Phosphaturic Mesenchymal Tumours, Mixed Connective Tissue Variant
Histopathology. 2017 Aug 31. doi: 10.1111/his.13377. [Epub ahead of print]

（６９）CREB1 Split Dual Color FISH Probe（SP059）
Angiomatoid fibrous histiocytoma: a series of seven cases including genetically confirmed aggressive cases and a literature review
BMC Musculoskeletal Disorders : 2017 18:31, (jp)

（６８）MDM2/CEN12p（GC020）, USP6 split（SP029）　Dual Color FISH Probe
HIF-1α, MDM2, CDK4, and p16 expression in ischemic fasciitis, focusing on its ischemic condition
Virchows Archiv : July 2017, Volume 471, Issue 1, pp 117–122 (jp)

（６７）FGFR1/ETO/CCNE2　TriColor FISH Probe
Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency
PLOS GENETICS : June 21, 2017 (jp)

（６６）CD274(PD-L1)/CEN9q Dual Color FISH Probe（GC141)
Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1+ immune cells in Epstein–Barr virus-associated gastric cancer: the prognostic implications
Mod Pathol. 2016 Dec 9. doi: 10.1038/modpathol.2016.202. [Epub ahead of print]

（６５）MYB Split Dual Color FISH Probe（SP016）
Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells
The Journal of Pathology : Volume 39, Issue 2, June 2016, pages 197 – 205

（６４）KRAS/CEN12q Dual Color FISH Probe（GC017）
Clonal evolution and KRAS-MET coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer
EMSO Open ( Cancer Horizons ) : 2016 1

（６３）CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma
MODERN PATHOLOGY : 2016, 00, 1-8

（６２）PLAG1/CEN8p Dual Color FISH Probe （GC114）
Prognostic factors in the myoepithelial-like spindle cell type of metaplastic breast cancer
Virchows Archiv : August 2016, Volume 469, Issue 2, pp 191–201

（６１）NF2/CEN22q Dual Color FISH Probe（GC003）
Intraoral Pseudo-Onion Bulb Intraneural Proliferations in a Patient with Hemimandibular Hyperplasia: A Case Report and Review of the Literature
Head Neck Pathol. 2016 Dec;10(4):475-480. Epub 2016 May 2.

（６０）ROS1 Split Dual Coloｒ　FISH Probe（SP015）
Expression levels of ROS1/ALK/c-MET and therapeutic efficacy of cetuximab plus chemotherapy in advanced biliary tract cancer
Sci Rep. 2016; 6: 25369.

（５９）BAP1/CEN3q Dual Color FISH Probe（GC097）
BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as a Diagnostic Tool in Malignant Pleural Mesothelioma Classification: A Large Retrospective Study
J Thorac Oncol. 2016 Nov;11(11):2006-2017. doi: 10.1016/j.jtho.2016.06.020. Epub 2016 Jul 13.

（５８）FGFR2/CEN10p Dual Color FISH Probe （GC018）
Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study
Cancer Research : Published OnlineFirst June 16, 2016

（５７）BRAF/CEN7q（GC115）, EGFR/CEN7q（GC005）, KRAS/CEN12q（GC017)　Dual Color FISH Probe
Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer
Cancer Research : Published OnlineFirst June 16, 2016

（５６）NTRK1 Split Dual Color FISH Probe（SP025）
NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer
Oncotarget. 2016 Feb 16; 7(7): 8399–8412.

（５５）NF2/CEN22q（GC003）, BAP1/CEN3q(GC097) 　and　 p16/CEN9q（GC002）　Dual Color FISH Probe
The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma
Modern Pathology; Augusta29.1 (Jan 2016): 14-24.

（５４）EGFR/CEN7q Dual Color FISH Probe（GC005）
Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer
Nature Communications 7 : Article number: 13665 (2016)

（５３）NF2/CEN22q Dual Color FISH Probe（GC003）
Clinical impact of targeted amplicon sequencing for meningioma as a practical clinical-sequencing system
Modern pathology 2017 Jul: 29(7) : 708-716
（５２）FGFR2 Split Dual Color FISH Probe
Distinct Clinicopathologic and Genetic Features of 2 Histologic Subtypes of Intrahepatic Cholangiocarcinoma The American Journal of Surgical Pathology, Volume 40, Number 8, 2016 (jp)

（５１）TFE3 split Dual Color FISH Probe（SP004）
Xp11.2/TFE3 translocation-associated renal cell carcinoma with multilocular cystic structures in an elderly patient: a case report
Int J Clin Exp Pathol 2016;9(3):3987-3992 (jp)

（５０）FGFR1 split Dual Color FISH Probe（GC055）
FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib
Cancer Science : November 2016, Volume 107, Issue 11, Pages 1667-1676 (jp)

（４９）ROS1 split Dual Color FISH Probe(SP015)
Pulmonary Neplasms in Patients with Birt-Hogg-Dube Syndrome: Histopathological Features and Genetic and Somatic Events
PLoS One. 2016 Mar 14;11(3):e0151476. doi: 10.1371/journal.pone.0151476. eCollection 2016.

（４８）CEN13q/18q/21q FISH Probe(CM3002)、CEN21q/Xp/Yq FISH Probe(CM3003)
J Obstet Gynaecol Res. 2016 May 2. doi: 10.1111/jog.12982. [Epub ahead of print]
Practicability of prenatal testing using lectin-based enrichment of fetal erythroblasts.

（４７）CEN17q FISH Probe(C017q)
Hum Pathol. 2016 Jun;52:74-82. doi: 10.1016/j.humpath.2016.01.004. Epub 2016 Feb 4.
Fluorescent and chromogenic in situ hybridization of CEN17q as a potent useful diagnostic marker for Birt-Hogg-Dubé syndrome-associated chromophobe renal cell carcinomas.

（４６）Subtelomere FISH Probe、CEN FISH Probe
J Hum Genet. 2016 May 19. doi: 10.1038/jhg.2016.39. [Epub ahead of print]
Reproductive outcomes following preimplantation genetic diagnosis using fluorescence in situ hybridization for 52 translocation carrier couples with a history of recurrent pregnancy loss

（４５）FGF9/CEN13q Dual Color FISH Probe（GC147）
Mol Carcinog. 2016 Feb 24. doi: 10.1002/mc.22476. [Epub ahead of print]
Significance of FGF9 gene in resistance to anti-EGFR therapies targeting colorectal cancer: A subset of colorectal cancer patients with FGF9 upregulation may be resistant to anti-EGFR therapies.

（４４）NCOA2 Split Dual Color FISH Probe（SP013）
Histopathology. 2016 Feb 4. doi: 10.1111/his.12943. [Epub ahead of print]
Histological Spectrum of Angiofibroma of Soft Tissue: Histological and genetic analysis of 13 cases.

（４３）KRAS/CEN12q Dual Color FISH Probe（GC017）
Br J Cancer. 2014 Oct 28;111(9):1788-801. doi: 10.1038/bjc.2014.475. Epub 2014 Aug 28.
KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.

（４２）IGH/SOX5, DY Translocation Dual Color FISH Probe（TR012）
Int J Hematol. 2015 Jun 27. [Epub ahead of print]
Identification of the SOX5 gene as a novel IGH-involved translocation partner in BCL2-negative follicular lymphoma with t(12;14)(p12.2;q32).

（４１）Chromosome Res. 2015 May 8. [Epub ahead of print]
Multicolor FISHs for simultaneous detection of genes and DNA segments on human chromosomes.

（４０）CAMTA1 Split Dual Color FISH Probe（SP032）
Histopathology. 2015 Apr 16. doi: 10.1111/his.12713. [Epub ahead of print]
CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma.

（３９）BRAF1/CEN7q Dual Color FISH Probe（GC115）
Oncol Lett. 2015 Feb;9(2):709-712. Epub 2014 Nov 20.
Increased BRAF copy number in lung adenocarcinoma.

（３８）FGFR3 Split Dual Color FISH Probe（SP011）
Mol Cancer Ther. 2015 Mar;14(3):704-12. doi: 10.1158/1535-7163.MCT-14-0927-T. Epub 2015 Jan 14.
Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1.

（３７）CDK4/CEN12q Dual Color FISH Probe（GC038）、
MDM2/CEN12p Dual Color FISH Probe（GC020）
Pathol Res Pract. 2015 Feb;211(2):117-24. doi: 10.1016/j.prp.2014.12.002. Epub 2014 Dec 11.
Malignant solitary fibrous tumor with high-grade nuclear atypia: an alternate entity for the undetermined tumor group.

（３６）c-met/CEN7q Dual Color FISH Probe （GC004）
BMC Cancer. 2015 Feb 6;15:31. doi: 10.1186/s12885-015-1019-1.
MET FISH-positive status predicts short progression-free survival and overall survival after gefitinib treatment in lung adenocarcinoma with EGFR mutation.

（３５）FGFR2/CEN10p Dual Color FISH Probe（GC018）
Cancer Sci. 2014 Jun 28. doi: 10.1111/cas.12470.
Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic
cancer.

(３４)RET Split Dual Color FISH Probe (SP018)
Mol Cancer Ther. 2014 Dec;13(12):2910-8. doi: 10.1158/1535-7163.MCT-14-0274. Epub 2014 Oct 27.
Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.

(３３)EML4/ALK, DY Translocation Dual Color FISH Probe (TR001)
J Thorac Oncol. 2014 Nov;9(11):1638-46. doi: 10.1097/JTO.0000000000000311.
A novel mechanism of EML4-ALK rearrangement mediated by chromothripsis in a patient-derived cell line.

（３２）FGFR2/CEN10p Dual Color FISH Probe（GC018）
Ann Surg Oncol. 2014 May;21(5):1561-8. doi: 10.1245/s10434-013-3456-x. Epub 2014 Jan 3.
Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets.

(３１)NCOA2 Split Dual Color FISH Probe(SP013)
Pathol Int. 2014 May;64(5):237-42. doi: 10.1111/pin.12163.
Angiofibroma of soft tissue with fibrohistiocytic features and intratumor genetic heterogeneity of NCOA2 gene rearrangement revealed by chromogenic in situ hybridization: a case report.

（３０）c-met/CEN7q Dual Color FISH Probe（GC004）
Oncotarget. 2014 Apr 30;5(8):2293-304.
Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.

（２９）ECT2/CEN3ｑ Dual Color FISH Probe（GC096）
Cancer Sci. 2014 Apr;105(4):490-7. doi: 10.1111/cas.12363. Epub 2014 Mar 19.
ECT2 amplification and overexpression as a new prognostic biomarker for early-stage lung adenocarcinoma.

（２８）c-met/CEN7q Dual Color FISH Probe（GC004）
Onco Targets Ther. 2014 Apr 3;7:513-24. doi: 10.2147/OTT.S60122. eCollection 2014.
Primary concomitant EGFR T790M mutation predicted worse prognosis in non-small cell lung cancer patients.

（２７）RET Split Dual Color FISH Probe(V.2) （SP019）
Mol Cancer Ther. 2014 Dec;13(12):2910-8. doi: 10.1158/1535-7163.MCT-14-0274. Epub 2014 Oct 27.
Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.

（２６）CCNE1/CEN19p Dual Color FISH Probe(GC013)
Mod Pathol. 2013 Dec 6. doi: 10.1038/modpathol.2013.209.
Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma.　

（２５）AKT3/CEN1q Dual Color FISH Probe(GC071)
Histopathology. 2013 Oct 19. doi: 10.1111/his.12313.
Investigation of molecular alterations of AKT-3 in triple-negative breast cancer.

（２４）ACTN4/CEN19p Dual Color FISH Probe(GC022)
Ann Oncol. 2013 Oct;24(10):2594-600. doi: 10.1093/annonc/mdt293. Epub 2013 Jul 30.
Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification.

（２３）CEN11q　FISH Probe
Pathol Int. 2013 Sep;63(9):469-75. doi: 10.1111/pin.12088. Epub 2013 Aug 28.
Collision of extensive exocrine and neuroendocrine neoplasms in multiple endocrine neoplasia type 1 revealed by cytogenetic analysis of loss of heterozygosity: a case report.

（２２）ALK/CEN2ｐ Dual Color FISH Probe （GC041）
J Clin Pathol. 2013 Aug;66(8):705-7. doi: 10.1136/jclinpath-2012-201329. Epub 2013 Apr 25.
Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma.

（２１） T/CEN6p Dual Color FISH Probe(GC079)
Journal of Neuropathology and Experimental Neurology, 72: 816-23, 2013
Molecular and Clinical Risk Factors for Recurrence of Skull Base Chordomas: Gain on Chromosome
2p, Expression of Brachyury, and Lack of Irradiation Negatively Correlate With Patient Prognosis.

（２０）PIK3CA/CEN3q Dual Color FISH Probe(GC077)
Chin J Cancer Res. 2013 Aug;25(4):416-22. doi: 10.3978/j.issn.1000-9604.2013.08.03.
PIK3CA mutation in Chinese patients with lung squamous cell carcinoma.

（１９） MYB Split Dual Color FISH Probe(SP016)
Ophthalmology. 2013 May 29. pii: S0161-6420(13)00315-1. doi: 10.1016/j.ophtha.2013.03.030. [Epub ahead of print]
Adenoid Cystic Carcinoma of the Lacrimal Gland: MYB Gene Activation, Genomic Imbalances, and
Clinical Characteristics.

（１８）FGFR1/CEN8q Dual Color FISH Probe(GC55)
Oral Oncol. 2013 Jun;49(6):576-81. doi: 10.1016/j.oraloncology.2013.01.006. Epub 2013 Feb 19.
Frequency of Fibroblast Growth Factor Receptor 1 gene amplification in oral tongue squamous cell
carcinomas and associations with clinical features and patient outcome.

（１７） ROS1 Split Dual Color FISH Probe(SP015)
Cancer. 2013 May 1;119(9):1627-35. doi: 10.1002/cncr.27967. Epub 2013 Feb 7.
Identification of ROS1 rearrangement in gastric adenocarcinoma.

（１６）FGF3,FGF4/CEN11ｐ Dual Color FISH Probe（GC63）
Hepatology. 2013 Apr;57(4):1407-15. doi: 10.1002/hep.25956. Epub 2013 Feb 11.
FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma.

（１５）CHOP Split Dual Color FISH Probe(SP014)
Article first published online: 21 FEB 2013　DOI: 10.1111/his.12068
Dedifferentiated liposarcoma with homologous lipoblastic differentiation: expanding the spectrum to
include low-grade tumours

（１４） c-met/CEN7q Dual Color FISH Probe（GC004）
Oncotarget. 2013 Jan;4(1):9-17.
MET amplification as a potential therapeutic target in gastric cancer.

（１３） ROS1 Split Dual Color FISH Probe（SP015)
Ann Surg Oncol. 2012 Aug 23.
ROS1 Receptor Tyrosine Kinase, a Druggable Target, is　Frequently Overexpressed in Non-Small Cell Lung Carcinomas　Via Genetic and Epigenetic Mechanisms

（１２）CALR/CEN19q Dual Color FISH Probe（GC033）
Am J Pathol. 2012 May;180(5):2076-83. doi: 10.1016/j.ajpath.2012.01.042. Epub 2012 Mar 17.
Aberrant calreticulin expression is involved in the dedifferentiation of dedifferentiated liposarcoma.

（１１） RET Split FISH Probe(V.2)(SP019), KIF5B/RET, SY FISH Probe(TR009)
Cancer Medicine, doi: 10.1002/cam4.13
RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer

（１０）FGFR2/CEN10p Dual Color FISH Probe(GC018)
British Journal of Cancer 106, 727-732 (14 February 2012)
FGFR2 gene amplification and clinicopathological features in gastric cancer

（９）RET Split Dual Color FISH Probe(SP018)
Nat Med. 2012 Feb 12.
KIF5B-RET fusions in lung adenocarcinoma.

（８）c-met/CEN7q Dual Color FISH Probe（GC004）
Lung Cancer. 2012 Jan;75(1):89-94. doi: 10.1016/j.lungcan.2011.06.004. Epub 2011 Jul 5.
Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients.

（７）NF2/CEN22q（GC003） ,1p36.33/CEN1p（GC030）, CHGA-ITPK1/CEN14ｑ(GC035) FISH Probe
J Clin Pathol. 2012 Jan;65(1):77-82. doi: 10.1136/jclinpath-2011-200208. Epub 2011 Nov 12.
Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues.

（６）TFE3 Split Dual Color FISH Probe(SP004)
Int J Clin Oncol. 2011 Oct;16(5):577-80. doi: 10.1007/s10147-010-0154-6. Epub 2010 Dec 15.
A case study of metastatic Xp11.2 translocation renal cell carcinoma effectively treated with sunitinib.

(５)SYT Split Dual Color FISH Probe(SP002),　EWS Dual Color FISH Probe(SP003)
Am J Clin Pathol. 2010 Aug;134(2):323-31.　
Detection of SYT and EWS gene rearrangements by dual-color break-apart CISH in liquid-based cytology samples of synovial sarcoma and Ewing sarcoma/primitive neuroectodermal tumor.

（４）p53/CEN17q Dual Color FISH Probe（GC011）
Clin Cancer Res. 2011 Apr 1;17(7):1731-40. doi: 10.1158/1078-0432.CCR-10-1996. Epub 2011 Feb 15.
Copy-neutral loss of heterozygosity at the p53 locus in carcinogenesis of esophageal squamous cell carcinomas associated with p53 mutations.

（３）SYT Split Dual Color FISH Probe(SP002)
Hum Pathol. 2010 Jun 29　 41：1394-404.　
Diagnostic utility of dual-color break-apart chromogenic in situ hybridization for the detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma.

（２）FFPE FISH Pretreatment kit2（K008）
Int J Cancer. 2009 Oct 15;125(8):1859-67. doi: 10.1002/ijc.24538.
Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression.

（１）EML4/ALK, DY Translocation Dual Color FISH Probe（TR001）
Clin Cancer Res. 2008 Oct 15;14(20):6618-24. doi: 10.1158/1078-0432.CCR-08-1018.
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.